Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Ursodeoxycholic Acid

Ted George O. Achufusi  1 , Anthony O. Safadi, Navid Mahabadi  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Ursodeoxycholic Acid

Ted George O. Achufusi et al.
Free Books & Documents

Excerpt

Ursodeoxycholic acid is a medication used to manage and treat cholestatic liver disease. This activity reviews the indications, mechanism of action, and contraindications for UDCA as a valuable agent in managing liver disease. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the interprofessional team performing patient management of cholestatic liver disease and related conditions.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Ted George Achufusi declares no relevant financial relationships with ineligible companies.

Disclosure: Anthony Safadi declares no relevant financial relationships with ineligible companies.

Disclosure: Navid Mahabadi declares no relevant financial relationships with ineligible companies.

References

    1. Guarino MP, Cocca S, Altomare A, Emerenziani S, Cicala M. Ursodeoxycholic acid therapy in gallbladder disease, a story not yet completed. World J Gastroenterol. 2013 Aug 21;19(31):5029-34. - PMC - PubMed
    1. Makino I, Tanaka H. From a choleretic to an immunomodulator: historical review of ursodeoxycholic acid as a medicament. J Gastroenterol Hepatol. 1998 Jun;13(6):659-64. - PubMed
    1. Roma MG, Toledo FD, Boaglio AC, Basiglio CL, Crocenzi FA, Sánchez Pozzi EJ. Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications. Clin Sci (Lond) 2011 Dec;121(12):523-44. - PubMed
    1. Lazaridis KN, Gores GJ, Lindor KD. Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders'. J Hepatol. 2001 Jul;35(1):134-46. - PubMed
    1. Copaci I, Micu L, Iliescu L, Voiculescu M. New therapeutical indications of ursodeoxycholic acid. Rom J Gastroenterol. 2005 Sep;14(3):259-66. - PubMed

Publication types

LinkOut - more resources