Cladribine
- PMID: 31424891
- Bookshelf ID: NBK545307
Cladribine
Excerpt
Multiple sclerosis is an immune-mediated inflammatory demyelinating disease of the central nervous system, resulting in loss of oligodendrocytes, astroglial scarring, and axonal injury (end-stage). Disease-modifying drugs help minimize long-term disability for people with multiple sclerosis by decreasing central nervous system inflammation, reducing the frequency and severity of acute attacks, delaying disease progression, and improving the overall quality of life. This activity covers cladribine, an established oral chemotherapy agent that the FDA recently approved for relapsing multiple sclerosis.
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References
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- Janiec K, Wajgt A, Kondera-Anasz Z. Effect of immunosuppressive cladribine treatment on serum leucocytes system in two-year clinical trial in patients with chronic progressive multiple sclerosis. Med Sci Monit. 2001 Jan-Feb;7(1):93-8. - PubMed
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- Niezgoda A, Losy J, Mehta PD. Effect of cladribine treatment on beta-2 microglobulin and soluble intercellular adhesion molecule 1 (ICAM-1) in patients with multiple sclerosis. Folia Morphol (Warsz) 2001 Aug;60(3):225-8. - PubMed
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- Bartosik-Psujek H, Belniak E, Mitosek-Szewczyk K, Dobosz B, Stelmasiak Z. Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. Acta Neurol Scand. 2004 Jun;109(6):390-2. - PubMed
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- Kopadze T, Döbert M, Leussink VI, Dehmel T, Kieseier BC. Cladribine impedes in vitro migration of mononuclear cells: a possible implication for treating multiple sclerosis. Eur J Neurol. 2009 Mar;16(3):409-12. - PubMed
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