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. 2019 Nov:254:106246.
doi: 10.1016/j.bpc.2019.106246. Epub 2019 Aug 9.

A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

D Benkerrou  1 , V Minicozzi  2 , A Gradogna  3 , S Milenkovic  1 , I V Bodrenko  4 , M Festa  5 , L Lagostena  3 , L Cornara  6 , A D'Amore  7 , M Ceccarelli  4 , A Filippini  7 , A Carpaneto  8
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A perspective on the modulation of plant and animal two pore channels (TPCs) by the flavonoid naringenin

D Benkerrou et al. Biophys Chem. 2019 Nov.

Abstract

The inhibitory effect of the flavonoid naringenin on plant and human Two-Pore Channels (TPCs) was assessed by means of electrophysiological measurements. By acting on human TPC2, naringenin, was able to dampen intracellular calcium responses to VEGF in cultured human endothelial cells and to impair angiogenic activity in VEGF-containing matrigel plugs implanted in mice. Molecular docking predicts selective binding sites for naringenin in the TPC structure, thus suggesting a specific interaction between the flavonoid and the channel.

Keywords: Animal lysosome; Fluorescence; Molecular docking; Patch-clamp; Plant vacuole; TPC channels.

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