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. 2019 Aug 19;9(1):12001.
doi: 10.1038/s41598-019-48529-y.

Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches

Diego López-Guerra  1 , Jesús Santos-Naharro  2 , Adela Rojas-Holguín  2 , Isabel Jaen-Torrejimeno  2 , Aranzazu Prada-Villaverde  2 , Gerardo Blanco-Fernández  2
Affiliations

Postoperative bleeding and biliary leak after liver resection: A cohort study between two different fibrin sealant patches

Diego López-Guerra et al. Sci Rep. .

Abstract

Different topical products have been tested in liver resection to get a control of bleeding. This study compares the effectiveness and complications between two haemostatic agents Tachosil versus Hemopatch. A cohort study including patients who underwent liver resection since November 2014 to April 2016 was conducted. The study was performed in a single institution. Demographic variables, intraoperative characteristics and postoperative complications were analysed. A total of 92 patients (50 in Tachosil group and 42 in Hemopatch group) were included. No differences were found in patients who required intraoperative (Tachosil 6 (12%) vs Hemopatch 2 (4.8%); p = 0.28) and postoperative (Tachosil 4 (8%) vs Hemopatch 3 (7.1%); p = 0.87) blood transfusion. There were no differences in length of hospital stay (Tachosil 7.02 ± 4.1 days vs Hemopatch 7.63 ± 9.1; p = 0.67). Overall postoperative complications were similar between both patches (Tachosil 21 (42%) vs Hemopatch 14 (33%); p = 0.48). No differences were found in specific complications, however Hemopatch showed a higher incidence of intraabdominal abscess 5 (11.9%) and vs 0 (0%) p = 0.01.In this study no differences have been found between Hemopatch and Tachosil in the effectiveness and overall postoperative complication after liver resection, although Hemopatch shows a higher incidence of intraabdominal abscess. Further studies are necessary to confirm these findings.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flowchart showing distribution in both hemostatic groups.
Figure 2
Figure 2
Postoperative biochemical parameters at registered at day 1, 3 and 5. Values are mean in each postoperative day.
See this image and copyright information in PMC

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