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Review
. 2019 Jul 25:2019:3018349.
doi: 10.1155/2019/3018349. eCollection 2019.

Diagnostic Performance of 18F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Giorgio Treglia  1   2   3
Affiliations
Review

Diagnostic Performance of 18F-FDG PET/CT in Infectious and Inflammatory Diseases according to Published Meta-Analyses

Giorgio Treglia. Contrast Media Mol Imaging. .

Abstract

Purpose: To date, several meta-analyses have reported data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases. This article aims to summarize the published evidence-based data about the diagnostic performance of 18F-FDG PET/CT in this setting.

Methods: A comprehensive computer literature search of meta-analyses published in PubMed/MEDLINE and Cochrane library database from January 2009 through December 2018 and regarding the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases was carried out. This combination of key words was used: (i) "PET" OR "positron emission tomography" OR "FDG" OR "fluorodeoxyglucose" AND (ii) meta-analysis. Only records on inflammatory or infectious diseases were selected.

Results: The diagnostic performance of 18F-FDG PET/CT in detecting inflammatory and infectious diseases has been summarized taking into account 36 meta-analyses published in the literature. Evidence-based data demonstrated good diagnostic performance of 18F-FDG PET/CT for several inflammatory and infectious diseases, in particular cardiovascular infectious and inflammatory diseases and some musculoskeletal infections.

Conclusions: Evidence-based data about the diagnostic performance of 18F-FDG PET/CT in infectious and inflammatory diseases are increasing, with good diagnostic performance of this imaging method for some indications. More prospective multicenter studies and cost-effective analyses are warranted.

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Examples of infectious and inflammatory diseases detected by 18F-FDG PET/CT: systemic sarcoidosis with pulmonary and mediastinal involvement (upper left), large vessel vasculitis associated with inflammatory rheumatic disease (lower left), spondylodiscitis (upper right), periprosthetic joint infection (middle right), and vascular graft infection (lower right).
See this image and copyright information in PMC

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