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. 1988 Oct;41(10):1331-7.
doi: 10.7164/antibiotics.41.1331.

Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity

M Oka  1 , Y Nishiyama, S Ohta, H Kamei, M Konishi, T Miyaki, T Oki, H Kawaguchi
Affiliations

Glidobactins A, B and C, new antitumor antibiotics. I. Production, isolation, chemical properties and biological activity

M Oka et al. J Antibiot (Tokyo). 1988 Oct.

Abstract

New antitumor antibiotic glidobactins A, B and C were isolated from the cultured broth of a gliding bacterium, Polyangium brachysporum sp. nov. No. K481-B101. They are novel molecules carrying the common cyclic tripeptide nucleus substituted with different alpha, beta, gamma, delta-unsaturated fatty acids. Glidobactins exhibit broad inhibitory activity against fungi and yeasts, and prolong the life span of mice inoculated with P388 leukemia cells.

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