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. 2019 Jul 24:2019:8079368.
doi: 10.1155/2019/8079368. eCollection 2019.

Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis

Vitaly G Bychkov  1 , Ludmila F Kalyonova  2 , Elena D Khadieva  3 , Semen D Lazarev  1 , Ilgiz R Lukmanov  3 , Vladimir A Shidin  1 , Evgeny N Morozov  4   5
Affiliations

Dynamics of the O. felineus Infestation Intensity and Egg Production in Carcinogenesis and Partial Hepatectomy in the Setting of Superinvasive Opisthorchiasis

Vitaly G Bychkov et al. Anal Cell Pathol (Amst). .

Abstract

Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. The smallest changes in the infestation intensity indicators and egg production were observed in the experimental stomach tumours (p > 0.05). A partial hepatectomy in the setting of opisthorchiasis did not affect the number of parasites in the ecological niche (liver) or the production of eggs by the helminth. With the deterioration of the vegetation state, parasite clumps of opisthorchii increase egg production under the conditions of distress.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Cholangiocellular tumour with a forming coarse stroma in the setting of superinvasive opisthorchiasis (SO) was visualized with haematoxylin and eosin (HE) staining, magnification 200x (1: tumour glandular complexes; 2: forming coarse stroma).
Figure 2
Figure 2
Undifferentiated cancer in the setting of SO. Opposition growth. HE staining, magnification 200x (1: undifferentiated tumour cells; 2: normal liver cells; 3: cholangiocyte adenomatous proliferates).
Figure 3
Figure 3
Opisthorchii in a duct located remotely from the tumour (showed by arrow). HE staining, magnification 200x.
Figure 4
Figure 4
Clumps of opisthorchii in cholangiectasis in liver cancer in the setting of SO. HE staining, magnification 100x (1: mature parasites; 2: immature parasites).
Figure 5
Figure 5
Experimental cholangiocarcinoma with a coarse stroma in the setting of SO. Van Gieson's staining, light microscopy magnification 20x (1: tumour glandular complexes; 2: coarse stroma).
Figure 6
Figure 6
Experimental cholangiocarcinoma with a tender stroma in the setting of SO. HE staining, magnification 200x (1: adenocarcinoma).
Figure 7
Figure 7
Experimental cholangiocarcinoma with a tender stroma in the setting of SO. HE staining, magnification 200x (1: adenocarcinoma; 2: coarse cholangiectasis wall; 3: opisthorchii in cholangiectasis).
Figure 8
Figure 8
Experimental pancreatic cancer in the setting of SO, IHC reaction with antibodies against cytokeratin-19 receptors, magnification 100x (1: cyst component; 2: papillary component; 3: tumour stroma).
Figure 9
Figure 9
Experimental gastrointestinal stromal tumour (GIST), IHC reaction with antibodies against CD117 receptors, magnification 200x (1: tumour elements from cells of Cajal).
See this image and copyright information in PMC

References

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