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Review
. 2020 Jan;39(1):19-30.
doi: 10.1007/s10096-019-03680-2. Epub 2019 Aug 20.

Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals

Amjad Hayat Khan  1 , Rahmah Noordin  2
Affiliations
Review

Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals

Amjad Hayat Khan et al. Eur J Clin Microbiol Infect Dis. 2020 Jan.

Abstract

Infection by Toxoplasma gondii is prevalent worldwide. The parasite can infect a broad spectrum of vertebrate hosts, but infection of fetuses and immunocompromised patients is of particular concern. Easy-to-perform, robust, and highly sensitive and specific methods to detect Toxoplasma infection are important for the treatment and management of patients. Rapid diagnostic methods that do not sacrifice the accuracy of the assay and give reproducible results in a short time are highly desirable. In this context, rapid diagnostic tests (RDTs), especially with point-of-care (POC) features, are promising diagnostic methods in clinical microbiology laboratories, especially in areas with minimal laboratory facilities. More advanced methods using microfluidics and sensor technology will be the future trend. In this review, we discuss serological and molecular-based rapid diagnostic tests for detecting Toxoplasma infection in humans as well as animals.

Keywords: Immunoassay; Molecular diagnostics; Point-of-care test; Rapid diagnostic tests; Toxoplasma gondii; Toxoplasma infection.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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