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. 2020 Mar;98(2):e261-e262.
doi: 10.1111/aos.14216. Epub 2019 Aug 19.

Vitreoschisis-induced vitreous cortex remnants: missing link in proliferative vitreoretinopathy

Koen van Overdam  1
Affiliations

Vitreoschisis-induced vitreous cortex remnants: missing link in proliferative vitreoretinopathy

Koen van Overdam. Acta Ophthalmol. 2020 Mar.
No abstract available

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Figures

Figure 1
Figure 1
Updated, redesigned version of the schematic diagram of anomalous PVD (Sebag et al. 2014), including the ‘missing link’ (indicated in red). The original version showed that PVD can be full thickness (without VCR) or partial thickness (vitreoschisis with VCR). Full thickness PVD may lead to peripheral traction (which may result in a retinal tear and detachment), posterior traction (which may result in vitreomacular or vitreopapillary traction/adhesion and macular hole) or no traction (without vitreoretinopathy). Partial thickness PVD may lead to VCR over the macula (posterior membrane), which may result in a macular hole or macular pucker (depending on membrane thickness, presence of hyalocytes and vitreopapillary adhesion). In this updated version, the diagram is completed by adding that not only full, but also partial thickness PVD can lead to peripheral and posterior traction, but most importantly by adding the ‘missing link’: anomalous PVD with vitreoschisis can lead to VCR over the (mid)peripheral retina (peripheral membrane), which can act like a scaffold for fibrocellular proliferation, in which RPE cells from retinal tears and hyalocytes in VCR, together with previously identified PVR risk factors, conspire to form PVR membranes.
See this image and copyright information in PMC

References

    1. Joeres S, Kirchhof B & Joussen AM (2006): PVR as a complication of rhegmatogeneous retinal detachment: a solved problem? Br J Ophthalmol 90: 796–797. - PMC - PubMed
    1. Sakamoto T & Ishibashi T (2009): Visualizing vitreous in vitrectomy by triamcinolone. Graefes Arch Clin Exp Ophthalmol 247: 1153–1163. - PubMed
    1. Sebag J (2008): Vitreoschisis. Graefes Arch Clin Exp Ophthalmol 246: 329–332. - PMC - PubMed
    1. Sebag J, Niemeyer M & Koss MJ (2014): Anomalous Posterior Vitreous Detachment and Vitreoschisis In: Sebag L (ed.) Vitreous: in health and disease. Heidelberg, Germany: Springer; 24: 1–262.
    1. Sonoda KH, Sakamoto T, Enaida H et al. (2004): Residual vitreous cortex after surgical posterior vitreous separation visualized by intravitreous triamcinolone acetonide. Ophthalmology 111: 226–230. - PubMed