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. 1988 Dec;113(6):1074-7.
doi: 10.1016/s0022-3476(88)80585-7.

Abnormalities of diaphragmatic muscle in neonates with ventilated lungs

A S Knisely  1 , S M Leal, D B Singer
Affiliations

Abnormalities of diaphragmatic muscle in neonates with ventilated lungs

A S Knisely et al. J Pediatr. 1988 Dec.

Abstract

Several infants and neonates who had received long-term ventilatory assistance had subnormal diaphragmatic muscle mass on gross necropsy examination. We conducted a retrospective study of our hospital infant necropsy files to determine whether prolonged ventilatory support was associated with diminution in myofiber cross-sectional area selectively affecting the diaphragm. We found that long-term ventilatory assistance may predispose diaphragmatic myofibers to disuse atrophy or to failure or normal growth. This phenomenon may contribute to difficulties in weaning infants from ventilatory support.

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