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. 1988 Dec;85(23):9312-6.
doi: 10.1073/pnas.85.23.9312.

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

G Q Daley  1 , D Baltimore
Affiliations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein

G Q Daley et al. Proc Natl Acad Sci U S A. 1988 Dec.

Abstract

The P210bcr/abl protein is associated with virtually every case of human chronic myelogenous leukemia. Unlike the related P160gag/v-abl oncogene product of Abelson murine leukemia virus, P210bcr/abl does not transform NIH 3T3 fibroblasts. To assess whether P210bcr/abl might transform hematopoietic cell types, retroviral constructs encoding P210bcr/abl were used to infect the bone marrow-derived interleukin 3-dependent Ba/F3 cell line. As for P160gag/v-abl, cell lines expressing P210bcr/abl were growth factor independent and tumorigenic in nude mice. No evidence for autocrine production of interleukin 3 by factor-independent cell lines was found. These experiments establish that P210bcr/abl can transform hematopoietic cell types to tumorigenicity.

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References

    1. Cancer Res. 1970 Aug;30(8):2208-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1985 May;82(10):3306-10 - PubMed
    1. Nature. 1975 Feb 27;253(5494):729-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 May;72(5):1932-6 - PubMed
    1. J Virol. 1981 Oct;40(1):164-72 - PubMed

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