MDSCs: friend or foe in systemic lupus erythematosus

Jianjian Ji^#^{1

2

3}, Pengfei Li^#⁴, Cunsi Shen¹, Huan Dou², Tingting Wang², Liyun Shi⁵, Yayi Hou⁶

Affiliations

¹ Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, 210023, Nanjing, China.
² The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China.
³ Key Laboratory of Inflammation and Immunoregulation, School of Medical and Life Science, Nanjing University of Chinese Medicine, 210046, Nanjing, China.
⁴ Department of Clinical Laboratory, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
⁵ Key Laboratory of Inflammation and Immunoregulation, School of Medical and Life Science, Nanjing University of Chinese Medicine, 210046, Nanjing, China. shi_liyun@msn.com.
⁶ The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China. yayihou@nju.edu.cn.

^# Contributed equally.

Jianjian Ji et al. Cell Mol Immunol. 2019 Dec.

. 2019 Dec;16(12):937-939.

doi: 10.1038/s41423-019-0271-8. Epub 2019 Aug 20.

Jianjian Ji^#^{1

2

3}, Pengfei Li^#⁴, Cunsi Shen¹, Huan Dou², Tingting Wang², Liyun Shi⁵, Yayi Hou⁶

¹ Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Affiliated Hospital of Nanjing University of Chinese Medicine, 210023, Nanjing, China.
² The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China.
³ Key Laboratory of Inflammation and Immunoregulation, School of Medical and Life Science, Nanjing University of Chinese Medicine, 210046, Nanjing, China.
⁴ Department of Clinical Laboratory, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, Jiangsu, China.
⁵ Key Laboratory of Inflammation and Immunoregulation, School of Medical and Life Science, Nanjing University of Chinese Medicine, 210046, Nanjing, China. shi_liyun@msn.com.
⁶ The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology and Hospital of Stomatology, Medical School, Nanjing University, Nanjing, China. yayihou@nju.edu.cn.

^# Contributed equally.

No abstract available

Conflict of interest statement

The authors declare no competing interests.

1. Lu Y, et al. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1alpha-dependent glycolysis. Cell Mol. Immunol. 2018;15:618–629. doi: 10.1038/cmi.2017.5. - DOI - PMC - PubMed
1. Veglia F, Perego M, Gabrilovich D. Myeloid-derived suppressor cells coming of age. Nat. Immunol. 2018;19:108–119. doi: 10.1038/s41590-017-0022-x. - DOI - PMC - PubMed
1. Wu H, et al. Arginase-1-dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus. Sci. Transl. Med. 2016;8:331ra40. doi: 10.1126/scitranslmed.aae0482. - DOI - PMC - PubMed
1. Ji J, et al. Myeloid-derived suppressor cells contribute to systemic lupus erythaematosus by regulating differentiation of Th17 cells and Tregs. Clin. Sci. 2016;130:1453–1467. doi: 10.1042/CS20160311. - DOI - PubMed
1. Trigunaite A, et al. Gr-1(high) CD11b+ cells suppress B cell differentiation and lupus-like disease in lupus-prone male mice. Arthritis Rheumatol. 2013;65:2392–2402. doi: 10.1002/art.38048. - DOI - PubMed