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Review
. 2019 Aug;54(Suppl 2):793-797.
doi: 10.1038/s41409-019-0603-4.

Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance

Robert Lowsky  1 , Samuel Strober  2
Affiliations
Review

Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance

Robert Lowsky et al. Bone Marrow Transplant. 2019 Aug.

Abstract

Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed chimerism, immune tolerance, and complete immunosuppressive drug withdrawal. Tolerance, persistent mixed chimerism, and complete withdrawal was achieved in the majority of fully matched patients. Persistent mixed chimerism and partial withdrawal has been achieved in the haplotype matched patients at present.

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Conflict of interest statement

Conflict of interest SS and RL receive consulting fees and owns equity in Medeor Therapeutics Inc., and receive royalties payments on patents held by their employer.

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