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. 2019 Aug 19;17(3):eAE4510.
doi: 10.31744/einstein_journal/2019AE4510.

Consensus on the investigation of thrombophilia in women and clinical management

[Article in English, Portuguese]
Claudia Mac Donald Bley Nascimento  1 , Andréa Maria Novaes Machado  1 , João Carlos de Campos Guerra  1 , Eduardo Zlotnik  1 , Dirceu Hamilton Cordeiro Campêlo  1 , Paulo Kauffman  2 , Hilton Waksman  1 , Nelson Wolosker  1 , Sérgio Podgaec  1 , Nelson Hamerschlak  1
Affiliations

Consensus on the investigation of thrombophilia in women and clinical management

[Article in English, Portuguese]
Claudia Mac Donald Bley Nascimento et al. Einstein (Sao Paulo). .

Abstract
in English, Portuguese

Objective: To standardize the investigation and clinical management of women with laboratory and/or clinical abnormalities suggestive of thrombophilia, in order to optimize antithrombotic approach and indication of laboratory tests.

Methodology: A discussion was carried out among 107 physicians (gynecologists/obstetricians, hematologists and vascular surgeons) present at a forum held at the Hospital Israelita Albert Einstein, in São Paulo (SP), Brazil. As a minimum criterion, 80% agreement was established in the voting to each recommendation of conduct in the final document. The cases in which there was agreement below 80% were discussed again, reaching a consensual agreement of conduct for the document writing.

Conclusion: The standardization of an institutional consensus of suggestions of clinical approach contributes to a better management of the group to be evaluated and minimizes risks of intercurrent events. This was the first national consensus on the investigation of thrombophilia in women.

Objetivo: Padronizar a investigação e o manejo clínico de mulheres com anormalidades clínicas e exames laboratoriais sugestivos de trombofilia, para melhorar a abordagem antitrombótica e otimizar a indicação de exames laboratoriais.

Metodologia: Foi conduzida discussão incluindo 107 médicos (ginecologistas/obstetras, hematologistas e cirurgiões vasculares) participantes de um fórum realizado no Hospital Israelita Albert Einstein, em São Paulo (SP). Como critério mínimo, estabeleceu-se concordância de 80% em votação para cada recomendação de conduta registrada em documento como diretrizes finais. Os casos em que a concordância esteve abaixo de 80% foram rediscutidos, para definir consenso na conduta.

Conclusão: A padronização e o estabelecimento de consenso institucional, com sugestões para abordagem clínica, contribui para melhorar o manejo do grupo a ser avaliado e minimizar os riscos de intercorrências. Este foi o primeiro consenso nacional sobre investigação de trombofilia em mulheres.

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Conflict of interest statement

Conflict of interest: none.

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