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Review
. 2019 Oct 7;58(41):14420-14426.
doi: 10.1002/anie.201907729. Epub 2019 Aug 21.

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

Frances H Arnold  1
Affiliations
Review

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

Frances H Arnold. Angew Chem Int Ed Engl. .

Abstract

The directed evolution of enzymes is now routinely used to develop new catalysts with various applications, such as in environmentally friendly production of chemicals and renewable fuels. In her Nobel lecture, F. Arnold describes how lessons from nature inspired the development of methods for directed evolution.

Keywords: biocatalysis; directed evolution; enzymes; protein engineering; synthetic methods.

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References

    1. J. L. Borges, The Library of Babel, Editorial Sur, 1941.
    1. “Natural Selection and the Concept of a Protein Space”: J. Maynard-Smith, Nature 1970, 225, 563-564.
    1. “The Library of Maynard Smith: My Search for Meaning in the Protein Universe”: F. H. Arnold, Microbe, ASM News, 2011, 6, 316-318.
    1. “Evolutionary Molecular Engineering Based on RNA Replication”: M. Eigen, W. Gardiner, Pure. Appl. Chem. 1984, 56, 967-978.
    1. “Directed Evolution of an RNA Enzyme”: A. A. Beaudry, G. F. Joyce, Science 1992, 257, 635-641.

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