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. 2019 Sep 16;55(72):10673-10676.
doi: 10.1039/c9cc04967c. Epub 2019 Aug 21.

Liquid-liquid phase separation rescues the conformational stability of a DNA hairpin from pressure-stress

Loana Arns  1 , Roland Winter  1
Affiliations

Liquid-liquid phase separation rescues the conformational stability of a DNA hairpin from pressure-stress

Loana Arns et al. Chem Commun (Camb). .

Abstract

We used single-molecule FRET experiments to monitor the conformational equilibrium of a DNA hairpin under pressure-stress in the presence of an aqueous two-phase system mimicking intracellular liquid-liquid phase separation (LLPS). Our data demonstrate the important role of LLPS with its immanent strong excluded volume effect in rescuing biological function under harsh environmental conditions.

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