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Editorial
. 2019 Sep;39(9):1702-1704.
doi: 10.1161/ATVBAHA.119.313110. Epub 2019 Aug 21.

Gone With the Vane

Emily R Legan  1 , Renhao Li  1
Affiliations
Editorial

Gone With the Vane

Emily R Legan et al. Arterioscler Thromb Vasc Biol. 2019 Sep.
No abstract available

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Conflict of interest statement

Disclosures

Authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Turbulent flow results in rapid cleavage and size reduction of VWF multimers.
Schematic of laminar and turbulent flow regimes exert differential forces on VWF multimers. The force exerted by the two regimes yield differences in the exposure of the cryptic ADAMTS13 cleavage site in the A2 domain (open circles), resulting in two distinct multimer distribution profiles (adapted from ref. 16). Turbulent flow regime results in excessive loss in ultra large VWF multimers (ULVWF), reminiscent of multimer distribution in type 2A VWD.
See this image and copyright information in PMC

Comment on

References

    1. Kirklin JK, Pagani FD, Kormos RL, Stevenson LW, Blume ED, Myers SL, Miller MA, Baldwin JT, Young JB, Naftel DC. Eighth annual INTERMACS report: Special focus on framing the impact of adverse events. J Heart Lung Transplant 2017;36:1080–1086. - PubMed
    1. Rose EA, Gelijns AC, Moskowitz AJ, Heitjan DF, Stevenson LW, Dembitsky W, Long JW, Ascheim DD, Tierney AR, Levitan RG, Watson JT, Meier P, Ronan NS, Shapiro PA, Lazar RM, Miller LW, Gupta L, Frazier OH, Desvigne-Nickens P, Oz MC, Poirier VL, Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure Study G. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 2001;345:1435–1443. - PubMed
    1. Tsiouris A, Paone G, Nemeh HW, Brewer RJ, Morgan JA. Factors determining post-operative readmissions after left ventricular assist device implantation. J Heart Lung Transplant 2014;33:1041–1047. - PubMed
    1. Crow S, Chen D, Milano C, Thomas W, Joyce L, Piacentino V 3rd, Sharma R, Wu J, Arepally G, Bowles D, Rogers J, Villamizar-Ortiz N. Acquired von Willebrand syndrome in continuous-flow ventricular assist device recipients. Ann Thorac Surg 2010;90:1263–1269. - PubMed
    1. Nascimbene A, Neelamegham S, Frazier OH, Moake JL, Dong JF. Acquired von Willebrand syndrome associated with left ventricular assist device. Blood 2016;127:3133–3141. - PMC - PubMed