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Comment
. 2019 Aug 20;51(2):201-203.
doi: 10.1016/j.immuni.2019.07.005.

Sweet Memories of 8 Empowered by Butyrate

Liangliang Ji  1 , Xiaoyu Hu  2
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Sweet Memories of 8 Empowered by Butyrate

Liangliang Ji et al. Immunity. .
Free article

Abstract

Formation of memory T cells is coupled with changes of metabolic status, yet how environmental metabolites affect the transition remains largely unknown. In this issue of Immunity, Bachem et al. (2019) report that microbiota-derived butyrate enhances the memory potential of CD8+ T cells via rewiring cellular metabolism.

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  • Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells.
    Bachem A, Makhlouf C, Binger KJ, de Souza DP, Tull D, Hochheiser K, Whitney PG, Fernandez-Ruiz D, Dähling S, Kastenmüller W, Jönsson J, Gressier E, Lew AM, Perdomo C, Kupz A, Figgett W, Mackay F, Oleshansky M, Russ BE, Parish IA, Kallies A, McConville MJ, Turner SJ, Gebhardt T, Bedoui S. Bachem A, et al. Immunity. 2019 Aug 20;51(2):285-297.e5. doi: 10.1016/j.immuni.2019.06.002. Epub 2019 Jul 1. Immunity. 2019. PMID: 31272808

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