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Comment
. 2019 Aug 20;51(2):206-208.
doi: 10.1016/j.immuni.2019.07.004.

B Cells Hit a Class Ceiling in the Germinal Center

Lucy Cooper  1 , Kim L Good-Jacobson  2
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Comment

B Cells Hit a Class Ceiling in the Germinal Center

Lucy Cooper et al. Immunity. .
Free article

Abstract

Class-switch recombination (CSR) provides diverse effector functions to B cells. In this issue of Immunity, Roco et al. (2019) refute long-standing dogma that germinal centers are the principal location for CSR; instead, CSR predominantly occurs early post immunization and declines during germinal center formation.

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  • Class-Switch Recombination Occurs Infrequently in Germinal Centers.
    Roco JA, Mesin L, Binder SC, Nefzger C, Gonzalez-Figueroa P, Canete PF, Ellyard J, Shen Q, Robert PA, Cappello J, Vohra H, Zhang Y, Nowosad CR, Schiepers A, Corcoran LM, Toellner KM, Polo JM, Meyer-Hermann M, Victora GD, Vinuesa CG. Roco JA, et al. Immunity. 2019 Aug 20;51(2):337-350.e7. doi: 10.1016/j.immuni.2019.07.001. Epub 2019 Jul 30. Immunity. 2019. PMID: 31375460 Free PMC article.

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