Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 21;9(1):198.
doi: 10.1038/s41398-019-0541-3.

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Breno S Diniz  1   2   3 , Charles F Reynolds Iii  4 , Etienne Sibille  5   6   7 , Mariska Bot  8 , Brenda W J H Penninx  8
Affiliations

Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults

Breno S Diniz et al. Transl Psychiatry. .

Abstract

Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP) index, a dynamic secretory molecular pattern indicative of cellular senescence. We also tested the potential moderators of the association between major depression and the SASP index. We included 1165 young and middle-aged adults (527 with a current major depressive episode (cMDE) and 638 with no lifetime history of depression) from a community-based cohort from the Netherlands. We calculated the SASP index based on a previously developed composite index involving 19 biomarkers. cMDE had higher SASP index values (t(1163) = 2.93, p = 0.003) compared to controls in the univariate analysis. After controlling for sociodemographic and somatic health covariates, there was no significant association between cMDE and SASP index (F(1,1158) = 1.09, p = 0.29). Those with the most severe depressive episodes had significantly higher SASP indices compared to those with mild-to-moderate cMDE and controls (F(2,1162) = 6.73, p = 0.001). We found a significant interaction between cMDE and overweight (F(1,1164) = 5.1, p = 0.028): those with comorbid cMDE and overweight had the highest SASP index. Our study demonstrated a complex interaction between cMDE and medical morbidity, especially overweight, on the SASP index, suggesting that their coexistence aggravate age-related biological processes. Moreover, higher SASP index can be a biomarker for more severe depressive episodes.

PubMed Disclaimer

Conflict of interest statement

B.P has received research funding from Janssen Research and Boehringer Ingelheim, not related to this study. The remaining authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Effect of the depression and overweight on SASP index values.
Subjects with current major depressive episode and overweight have the highest SASP index values compared to the other groups (omnibus ANOVA p-value < 0.001). We also found a significant interaction between the diagnosis of major depressive episode and weight (p = 0.024, see Table 3) on SASP index values. Pairwise comparisons (Depression and Overweight group as reference): *p = 0.001; **p < 0.001; ***p < 0.001
See this image and copyright information in PMC

References

    1. Byers AL, Yaffe K, Covinsky KE, Friedman MB, Bruce ML. High occurrence of mood and anxiety disorders among older adults: The national comorbidity survey replication. Arch. Gen. Psychiatry. 2010;67:489–496. doi: 10.1001/archgenpsychiatry.2010.35. - DOI - PMC - PubMed
    1. Hasin DS, et al. Epidemiology of adult dsm-5 major depressive disorder and its specifiers in the united states. JAMA Psychiatry. 2018;75:336–346. doi: 10.1001/jamapsychiatry.2017.4602. - DOI - PMC - PubMed
    1. Global Burden of Disease Study C. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;386:743–800. doi: 10.1016/S0140-6736(15)60692-4. - DOI - PMC - PubMed
    1. Vancampfort D, et al. Metabolic syndrome and metabolic abnormalities in patients with major depressive disorder: a meta-analysis of prevalences and moderating variables. Psychol. Med. 2014;44:2017–2028. doi: 10.1017/S0033291713002778. - DOI - PubMed
    1. Correll CU, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls. World Psychiatry. 2017;16:163–180. doi: 10.1002/wps.20420. - DOI - PMC - PubMed

Publication types