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Comment
. 2019 Oct;29(10):783-784.
doi: 10.1038/s41422-019-0218-8.

Mutagenic replication: target for tumor therapy?

Jacob G Jansen  1 , Niels de Wind  2
Affiliations
Comment

Mutagenic replication: target for tumor therapy?

Jacob G Jansen et al. Cell Res. 2019 Oct.
No abstract available

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Figures

Fig. 1
Fig. 1
Genotoxic chemotherapy exerts toxicity towards proliferating cells, including tumor cells and stem cells in tissues (left). The toxicity of chemotherapy-induced DNA damage is counteracted by TLS, at the expense of mutations that might contribute to tumor progression (red star) or to secondary tumorigenesis (green star). JH-RE-06 inhibits REV1-mediated mutagenic TLS. This results in sensitization of proliferating tumor cells (and, possibly, also of normal stem cells) to the toxic effects of chemotherapy, while avoiding the mutagenic consequences of TLS. Nevertheless, it cannot be excluded that systemic REV1 inactivation provokes undesired phenotypes (see the text)
See this image and copyright information in PMC

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