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Comparative Study
. 1987 Nov-Dec;1(6):339-46.
doi: 10.1016/0920-1211(87)90058-1.

A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients

E M Rimmer  1 , N M Milligan, A Richens
Affiliations
Comparative Study

A comparison of the acute effect of single doses of vigabatrin and sodium valproate on photosensitivity in epileptic patients

E M Rimmer et al. Epilepsy Res. 1987 Nov-Dec.

Abstract

The acute effect of oral administration of a single dose of vigabatrin, a new antiepileptic drug which acts by irreversible enzyme-activated inhibition of the brain enzyme, GABA-aminotransferase, on the photoconvulsive response in patients with photosensitive epilepsy, was compared with that of the established antiepileptic drug, sodium valproate. Both drugs significantly suppressed the photoconvulsive response in 3 out of 6 subjects. This result was interpreted as further evidence of vigabatrin's potential value in the future treatment of patients with epilepsy.

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