Centrosome Amplification and Tumorigenesis: Cause or Effect?

Abstract

Centrosome amplification is a feature of multiple tumour types and has been postulated to contribute to both tumour initiation and tumour progression. This chapter focuses on the mechanisms by which an increase in centrosome number might lead to an increase or decrease in tumour progression and the role of proteins that regulate centrosome number in driving tumorigenesis.

Keywords: Aneuploidy; Centriole; Centrosome; Chromosomal instability.