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Editorial
. 2019 Oct;64(10):2709-2716.
doi: 10.1007/s10620-019-05778-1.

Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too

Jonathan D Kaunitz  1   2   3 , Yasutada Akiba  4   5
Affiliations
Editorial

Control of Intestinal Epithelial Proliferation and Differentiation: The Microbiome, Enteroendocrine L Cells, Telocytes, Enteric Nerves, and GLP, Too

Jonathan D Kaunitz et al. Dig Dis Sci. 2019 Oct.

Erratum in

No abstract available

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Conflict of interest statement

Compliance with Ethical Standards

Conflicts of interest The authors are recipients of investigator-initiated grants from Shire Pharmaceuticals LLP.

Figures

Fig. 1
Fig. 1
Scanning electron micrograph (SEM) image of the PMS underlying the villous epithelial cells of rat intestine (*). Reproduced with permission from [49]
Fig. 2
Fig. 2
SEM of the PMS underlying the crypt and villus of rat jejunum, showing the syncytium of connected fibroblast-like cells. “E”: villous epithelium. Reproduced with permission from [47]
Fig. 3
Fig. 3
Simplified proposed model of the mechanisms controlling intestinal epithelial proliferation, migration, and differentiation. Abbreviations: SCFA short-chain fatty acids, GLP glucagon-like peptide, L lumen, MC mesenchymal cell, NO nitric oxide, PDGF platelet-derived growth factor, VIP vasoactive intestinal peptide. Insets: a: detail of interactions in the villous; b: detail of interactions in the crypt. For further details, see text
Fig. 4
Fig. 4
Timeline of major discoveries that provided the scientific basis for the development of therapeutic GLP-2 analogs
See this image and copyright information in PMC

References

    1. Mah AT, Kuo CJ. Home sweet home: a Foxl1(+) mesenchymal niche for intestinal stem cells. Cell Mol Gastroenterol Hepatol. 2016;2:116–117. - PMC - PubMed
    1. Haegebarth A, Clevers H. Wnt signaling, lgr5, and stem cells in the intestine and skin. Am J Pathol. 2009;174:715–721. - PMC - PubMed
    1. McCabe LR, Parameswaran N. Recent advances in intestinal stem cells. Curr Mol Biol Rep. 2017;3:143–148. - PMC - PubMed
    1. Yen TH, Wright NA. The gastrointestinal tract stem cell niche. Stem Cell Rev. 2006;2:203–212. - PubMed
    1. Mao SA, Glorioso JM, Nyberg SL. Liver regeneration. Transl Res. 2014;163:352–362. - PMC - PubMed

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