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. 2020 Feb;24(2):655-665.
doi: 10.1007/s10461-019-02638-x.

Differentiating Types of Self-Reported Alcohol Abstinence

Kirsha S Gordon  1   2 , Kathleen McGinnis  3 , Cecilia Dao  4 , Christopher T Rentsch  3   5 , Aeron Small  4 , Rachel Vickers Smith  6 , Rachel L Kember  7   8 , Joel Gelernter  3   4 , Henry R Kranzler  8   9 , Kendall J Bryant  10 , Janet P Tate  3   4 , Amy C Justice  3   4
Affiliations

Differentiating Types of Self-Reported Alcohol Abstinence

Kirsha S Gordon et al. AIDS Behav. 2020 Feb.

Abstract

We contrast three types of abstinence: quit after alcohol associated problems (Q-AP), quit for other reasons (Q-OR), and lifetime abstainer (LTA). We summarized the characteristics of people living with HIV (PLWH), and matched uninfected individuals, by levels of alcohol use and types of abstinence. We then identified factors that differentiate abstinence and determined whether the association with an alcohol biomarker or a genetic polymorphism is improved by differentiating abstinence. Among abstainers, 34% of PLWH and 38% of uninfected were Q-AP; 53% and 53% were Q-OR; and 12% and 10% were LTA. Logistic regression models found smoking, alcohol, cocaine, and hepatitis C increased odds of Q-AP, whereas smoking and marijuana decreased odds of LTA. Differentiating types of abstinence improved association. Q-APs and LTAs can be readily differentiated by an alcohol biomarker and genetic polymorphism. Differentiating type of abstinence may enhance understanding of alcohol health effects.

Keywords: ADH1B; Alcohol use disorder; HIV; Phosphatidylethanol; Veterans.

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

Figures

Figure 1.
Figure 1.. Current Alcohol Use by Age and HIV Status
PLHW – people living with HIV
Figure 2.
Figure 2.. Percent with PEth>20 ng/ml by AAM AUDIT-C and Abstainer Type
P for trend across all 6-levels, p = 3.20 × 10−79; across the 4-levels of AUDIT-C=0, p = 2.780 × 10−86
Figure 3.
Figure 3.. Percent with ADH1B rs2066702 Minor Allele by AAM AUDIT-C and Abstainer Type
P for trend across all 6-levels, p = 0.007; across the 4-levels of AUDIT-C=0, p =0.03
See this image and copyright information in PMC

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