doi: 10.1016/0014-5793(88)81051-2.
Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation
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- PMID: 3143604
- DOI: 10.1016/0014-5793(88)81051-2
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Metallothionein RNA levels in HL-60 cells. Effect of cadmium, differentiation, and protein kinase C activation
FEBS Lett.
.
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Abstract
Metallothionein (MT) gene transcription is regulated in a developmental and tissue-specific manner by metal ions and other agents. We examined MT expression in the human promyelocytic leukemia cell line HL-60 during differentiation along macrophage and neutrophil lineages. All HL-60 phenotypes showed similar basal levels of MT RNA with significant induction following exposure to Cd2+ but not activators of PKC. MT RNA did not correlate with growth state or with known levels of PKC activity, thus our data do not support a role for MT in HL-60 differentiation or for PKC in MT expression.
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