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Comparative Study
. 1988 Oct;79(10):1089-93.
doi: 10.1111/j.1349-7006.1988.tb01531.x.

Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin

H Fujiki  1 , M Suganuma, H Suguri, S Yoshizawa, K Takagi, N Uda, K Wakamatsu, K Yamada, M Murata, T Yasumoto, et al.
Affiliations
Comparative Study

Diarrhetic shellfish toxin, dinophysistoxin-1, is a potent tumor promoter on mouse skin

H Fujiki et al. Jpn J Cancer Res. 1988 Oct.

Abstract

Dinophysistoxin-1, 35-methylokadaic acid, is a causative agent of diarrhetic shellfish poisoning. The biological activities and tumor-promoting activity of dinophysistoxin-1 were studied together with those of okadaic acid and 7-O-palmitoyl okadaic acid. Dinophysistoxin-1 is a skin irritant and induces ornithine decarboxylase in mouse skin with the same potency as okadaic acid. 7-O-Palmitoyl okadaic acid induced a lower activity than the other compounds. Dinophysistoxin-1 inhibited the specific [3H]okadaic acid binding to a particulate fraction of mouse epidermis. The binding affinities of dinophysistoxin-1 and okadaic acid to a particulate fraction were almost the same. Dinophysistoxin-1 showed a tumor-promoting activity as strong as that of okadaic acid in a two-stage carcinogenesis experiment on mouse skin. The percentages of tumor-bearing mice in the groups treated with 100 micrograms of 7,12-dimethylbenz[a]anthracene (DMBA) followed by 5 micrograms of dinophysistoxin-1, twice a week, and with DMBA followed by 5 micrograms of okadaic acid twice a week were 86.7% and 80.0% in week 30, respectively. The average number of tumors per mouse was 4.6 in the former group and 3.9 in the latter. Dinophysistoxin-1 and okadaic acid act on cells through different pathways from the 12-O-tetradecanoylphorbol-13-acetate-type tumor promoters.

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References

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