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Review
. 2019 Aug 21;7(9):279.
doi: 10.3390/microorganisms7090279.

Microbiota and Immune-Mediated Skin Diseases-An Overview

Adrian Catinean  1 , Maria Adriana Neag  2 , Andrei Otto Mitre  3 , Corina Ioana Bocsan  4 , Anca Dana Buzoianu  4
Affiliations
Review

Microbiota and Immune-Mediated Skin Diseases-An Overview

Adrian Catinean et al. Microorganisms. .

Abstract

In recent years, increased attention has been paid to the relationship between microbiota and various diseases, especially immune-mediated diseases. Because conventional therapy for many autoimmune diseases is limited both in efficacy and safety, there is an increased interest in identifying nutraceuticals, particularly probiotics, able to modulate the microbiota and ameliorate these diseases. In this review, we analyzed the research focused on the role of gut microbiota and skin in immunity, their role in immune-mediated skin diseases (IMSDs), and the beneficial effect of probiotics in patients with this pathology. We selected articles published between 2009 and 2019 in PubMed and ScienceDirect that provided information regarding microbiota, IMSDs and the role of probiotics in these diseases. We included results from different types of studies including observational and interventional clinical trials or in vivo and in vitro experimental studies. Our results showed that probiotics have a beneficial effect in changing the microbiota of patients with IMSDs; they also influence disease progression. Further studies are needed to better understand the impact of new therapies on intestinal microbiota. It is also important to determine whether the microbiota of patients with autoimmune diseases can be manipulated in order to restore homeostasis of the microbiota.

Keywords: autoimmune skin diseases; immune-mediated diseases; microbiota; probiotics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Impact of endogenous and exogenous factors on the skin microbiome dashed line, normal (balanced) microbiota; red line, microbiota in pathologies
Figure 2
Figure 2
The role of SCFAs in immunomodulation Abbreviations: SCFAs, short chain fatty acids; HDAC, histone deacetylases; GPCR, G protein coupled receptors; HIF, hypoxia-inducible factor.
See this image and copyright information in PMC

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