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Case Reports
. 2019 Jul 28:45:82-85.
doi: 10.1016/j.amsu.2019.07.026. eCollection 2019 Sep.

Autoimmune pancreatitis masquerading as carcinoma head of pancreas: A case report and review of literature

Meenu Gill  1 , Komal Brar  1 , Rajesh Godara  2 , Shilpi Bhargava  1 , Bhawna Sachdeva  3 , Rajeev Sen  1 , Promil Jain  1
Affiliations
Case Reports

Autoimmune pancreatitis masquerading as carcinoma head of pancreas: A case report and review of literature

Meenu Gill et al. Ann Med Surg (Lond). .

Abstract

Introduction: Autoimmune pancreatitis (AIP) is a rare form of chronic inflammatory pancreatic disease secondary to an underlying autoimmune mechanism. It is now considered as pancreatic manifestation of IgG4 related disease, which is a multisystem disease.

Case report: We are reporting a patient who presented with obstructive jaundice and mass head of pancreas on Computed Tomography (CT) scan. Considering a strong clinical suspicion of pancreatic cancer, Whipple procedure was done. Histopathological report revealed intense lymphoplasmacytic infiltrate and fibrosis with collagenisation, so possibility of AIP was suggested. Serum IgG4 levels were advised and found to be increased. Diagnosis of AIP was made and patient responded to steroids.

Discussion: Pre-operative core biopsy of the pancreas and Serum IgG4 levels are sufficient to make the diagnosis and resection is usually not recommended in AIP.

Conclusion: Awareness of the entity and use of ancillary techniques in making the pre-operative diagnosis could have saved the patient from an extensive surgical procedure.

Keywords: AIP- Autoimmune Pancreatitis, CT-Computed Tomography; Autoimmune; Carcinoma; Pancreatitis.

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Figures

Fig. 1
Fig. 1
CECT Abdomen revealing bulky pancreatic head with lobulated outline and ill-defined hypodense mass lesion.
Fig. 2
Fig. 2
a&b: Dense stromal sclerosis (arrow head) and Lymphoplasmacytic infiltrate with acinar cell destruction (arrow); (H&E; 40x). c: Normal ductules showing cytoplasmic positivity (Immunohistochemistry,CK; 40x). d: Areas of dense fibrosis (Masson's Trichome stain; 40x).
See this image and copyright information in PMC

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