Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul 23:11:195-199.
doi: 10.2147/RRU.S220221. eCollection 2019.

Perioperative outcomes in elderly patients undergoing nephrectomy for renal cell carcinoma

Wichien Sirithanaphol  1 , Kachit Pachirat  1 , Ukrit Rompsaithong  1 , Pakorn Kiatsopit  1 , Piti Ungareevittaya  2 , Jarin Chindaprasirt  3
Affiliations

Perioperative outcomes in elderly patients undergoing nephrectomy for renal cell carcinoma

Wichien Sirithanaphol et al. Res Rep Urol. .

Abstract

Purpose: To determine if age should be considered a relative contraindication to surgery for safety reasons.

Methods: Renal cell carcinoma (RCC) patients who underwent nephrectomy from January 2007 to December 2017 were analyzed retrospectively. Patients were grouped into age<65 and age≥65 years. The demographic data, surgical outcomes, complication, hospital stay, blood loss, and survival were compared between the two groups.

Results: A total of 101 patients were included; 74 in the younger group, and 27 in the older group. Compared to the young group, lower BMI, higher anemia, higher ASA grade, and comorbidities were frequent in the elderly. The operative time, blood loss, and renal function decline were comparable between two age groups. The complication rates in the older and younger group were 22% and 12%, respectively. The survival time was shorter in older patients compared to the younger ones; hazard ratio 2.25; 95%CI 1.08-4.69, p-value=0.031.

Conclusion: Nephrectomy in elderly patients is safe and feasible and preoperative assessment along with diligent postoperative care may further increase survival. Age alone cannot be regarded as a contraindication for nephrectomy in RCC.

Keywords: aged population; geriatric; kidney cancer; kidney surgery.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Age at diagnosis.
Figure 2
Figure 2
Kaplan-Meier survival curve (age≥65vs <65) for non-metastatic RCC. (HR 2.25; 95% CI 1.08–4.69, p-value=0.031).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. United Nations Department of Economic and Social Affairs Population Division. World Population Ageing 2017 – Highlights (ST/ESA/SER.A/397); 2017. Available from: http://www.un.org/en/development/desa/population/publications/pdf/ageing.... Accessed 1 May, 2019.
    1. Wirasorn K, Suwanrungruang K, Sookprasert A, Limpawattana P, Sirithanaphol W, Chindaprasirt J. Hospital-based population of elderly cancer cases in Northeastern Thailand. Asian Pac J Cancer Prev. 2016;17(2):767–770. doi:10.7314/apjcp.2016.17.2.767 - DOI - PubMed
    1. Saad AM, Gad MM, Al-Husseini MJ, Ruhban IA, Sonbol MB, Ho TH. Trends in renal-cell carcinoma incidence and mortality in the United States in the last 2 decades: a SEER-based study. Clin Genitourin Cancer. 2019;17(1):46–57 e45. doi:10.1016/j.clgc.2018.10.002 - DOI - PMC - PubMed
    1. Colombo JR Jr., Haber GP, Jelovsek JE, Lane B, Novick AC, Gill IS. Seven years after laparoscopic radical nephrectomy: oncologic and renal functional outcomes. Urology. 2008;71(6):1149–1154. doi:10.1016/j.urology.2007.11.081 - DOI - PubMed
    1. Flanigan RC, Salmon SE, Blumenstein BA, et al. Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer. N Engl J Med. 2001;345(23):1655–1659. doi:10.1056/NEJMoa003013 - DOI - PubMed

LinkOut - more resources