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Comment
. 2019 Aug 22;178(5):1038-1040.
doi: 10.1016/j.cell.2019.07.052.

When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die

Roberta Buono  1 , Valter D Longo  2
Affiliations
Comment

When Fasting Gets Tough, the Tough Immune Cells Get Going-or Die

Roberta Buono et al. Cell. .

Abstract

Cycles of fasting reduce autoimmunity and activate lymphocyte-dependent killing of cancer cells, but the mechanisms remain poorly understood. Three studies in this issue of Cell begin to reveal the drastic and complex effects of fasting and severe calorie restriction on the levels and localization of different immune cells and the mechanisms responsible for them.

PubMed Disclaimer

Conflict of interest statement

DECLARATION OF INTERESTS

Valter Longo has equity interest in L-Nutra, a company that produces medical food.

Comment on

  • Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.
    Nagai M, Noguchi R, Takahashi D, Morikawa T, Koshida K, Komiyama S, Ishihara N, Yamada T, Kawamura YI, Muroi K, Hattori K, Kobayashi N, Fujimura Y, Hirota M, Matsumoto R, Aoki R, Tamura-Nakano M, Sugiyama M, Katakai T, Sato S, Takubo K, Dohi T, Hase K. Nagai M, et al. Cell. 2019 Aug 22;178(5):1072-1087.e14. doi: 10.1016/j.cell.2019.07.047. Cell. 2019. PMID: 31442401
  • The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
    Collins N, Han SJ, Enamorado M, Link VM, Huang B, Moseman EA, Kishton RJ, Shannon JP, Dixit D, Schwab SR, Hickman HD, Restifo NP, McGavern DB, Schwartzberg PL, Belkaid Y. Collins N, et al. Cell. 2019 Aug 22;178(5):1088-1101.e15. doi: 10.1016/j.cell.2019.07.049. Cell. 2019. PMID: 31442402 Free PMC article.
  • Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.
    Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, Wirtz TH, Naik S, Rose SA, Brocker CN, Gainullina A, Hornburg D, Horng S, Maier BB, Cravedi P, LeRoith D, Gonzalez FJ, Meissner F, Ochando J, Rahman A, Chipuk JE, Artyomov MN, Frenette PS, Piccio L, Berres ML, Gallagher EJ, Merad M. Jordan S, et al. Cell. 2019 Aug 22;178(5):1102-1114.e17. doi: 10.1016/j.cell.2019.07.050. Cell. 2019. PMID: 31442403 Free PMC article.

References

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