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. 2019 Nov-Dec;170(8):392-398.
doi: 10.1016/j.resmic.2019.08.003. Epub 2019 Aug 20.

Energy coupling in ABC exporters

Hendrik W van Veen  1 , Himansha Singh  2 , Kelvin Agboh  2 , Lisa A Fagg  2 , Dawei Guo  2 , Brendan Swain  2 , Robbin F de Kruijf  2 , Charlotte Guffick  2
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Free article

Energy coupling in ABC exporters

Hendrik W van Veen et al. Res Microbiol. 2019 Nov-Dec.
Free article

Abstract

Multidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins.

Keywords: ABC transporter; Bioenergetics; Multidrug transport; Transport mechanisms.

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