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Review
. 2019 Aug 15;11(8):1918.
doi: 10.3390/nu11081918.

Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice

Carlo Alfieri  1   2 , Oksana Ruzhytska  3 , Simone Vettoretti  1 , Lara Caldiroli  1 , Mario Cozzolino  2   4 , Piergiorgio Messa  5   6
Affiliations
Review

Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice

Carlo Alfieri et al. Nutrients. .

Abstract

Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called "unconventional effects" of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2-5 ND patients will be presented. In addition, it will focus on the "unconventional effects" of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2-5 ND.

Keywords: CKD; cardiovascular risk; mineral metabolism; vitamin D; vitamin D supplementation.

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Conflict of interest statement

No conflict of interest related to the present paper is declared.

Figures

Figure 1
Figure 1
Principal effects and their level of evidence of native hypovitaminosis D in chronic kidney disease (CKD) patients. LOE: level of evidence. ** slight level of evidence; *** moderate level of evidence; ***** strong level of evidence;
See this image and copyright information in PMC

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