Nodal metastases of soft tissue sarcomas: risk factors, imaging findings, and implications

Jeffrey Rosenthal¹, Kenneth Cardona², Samia K Sayyid¹, Adam J Perricone³, Nickolas Reimer⁴, David Monson⁴, Adam Daniel Singer⁵

Affiliations

¹ Department of Radiology and Imaging Sciences, Section of Musculoskeletal Imaging, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.
² Department of Surgical Oncology, Emory University Hospital, Atlanta, GA, USA.
³ Department of Pathology, Emory University Hospital, Atlanta, GA, USA.
⁴ Department of Orthopedic Surgery, Emory University Hospital, Atlanta, GA, USA.
⁵ Department of Radiology and Imaging Sciences, Section of Musculoskeletal Imaging, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA. adamsinger82@gmail.com.

PMID: 31444522
DOI: 10.1007/s00256-019-03299-6

Review

Nodal metastases of soft tissue sarcomas: risk factors, imaging findings, and implications

Jeffrey Rosenthal et al. Skeletal Radiol. 2020 Feb.

. 2020 Feb;49(2):221-229.

doi: 10.1007/s00256-019-03299-6. Epub 2019 Aug 23.

Authors

Jeffrey Rosenthal¹, Kenneth Cardona², Samia K Sayyid¹, Adam J Perricone³, Nickolas Reimer⁴, David Monson⁴, Adam Daniel Singer⁵

Affiliations

¹ Department of Radiology and Imaging Sciences, Section of Musculoskeletal Imaging, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA.
² Department of Surgical Oncology, Emory University Hospital, Atlanta, GA, USA.
³ Department of Pathology, Emory University Hospital, Atlanta, GA, USA.
⁴ Department of Orthopedic Surgery, Emory University Hospital, Atlanta, GA, USA.
⁵ Department of Radiology and Imaging Sciences, Section of Musculoskeletal Imaging, Emory University Hospital, 59 Executive Park South, 4th Floor, Suite 4009, Atlanta, GA, 30329, USA. adamsinger82@gmail.com.

PMID: 31444522
DOI: 10.1007/s00256-019-03299-6

Abstract

Soft tissue sarcomas (STS) are malignancies derived from connective tissue, and regional lymph node metastasis (RLNM), while not common, is an important aspect of prognosis and treatment. Various risk factors, in particular the histological subtype, affect the likelihood of nodal involvement, which can be characterized by imaging features such as nodal dimension and morphology. Currently, surveillance and management vary by institution, as concrete societal guidelines have not been established. Common nodal status assessment strategies include physical exam, US CT, MRI, sentinel lymph node biopsy (SLNB) and radical lymphadenectomy. This article summarizes data regarding relevant risk factors of RLNM, imaging features, and any available data regarding surveillance recommendations.

Keywords: Histology; Lymph node; Nodal metastasis; Oncology; SCARE; Soft tissue sarcoma.

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Nodal metastases of soft tissue sarcomas: risk factors, imaging findings, and implications

Affiliations

Nodal metastases of soft tissue sarcomas: risk factors, imaging findings, and implications

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Medical