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Meta-Analysis
. 2020 Oct;26(4):2049-2056.
doi: 10.1007/s12253-019-00727-9. Epub 2019 Aug 23.

Accuracy of One-Step Nucleic Acid Amplification in Detecting Lymph Node Metastases in Endometrial Cancer

Antonio Raffone  1 , Antonio Travaglino  2 , Angela Santoro  3 , Italia Esposito  4 , Giuseppe Angelico  3 , Saveria Spadola  3 , Gian Franco Zannoni  3
Affiliations
Free article
Meta-Analysis

Accuracy of One-Step Nucleic Acid Amplification in Detecting Lymph Node Metastases in Endometrial Cancer

Antonio Raffone et al. Pathol Oncol Res. 2020 Oct.
Free article

Abstract

One-step nucleic acid amplification (OSNA) is used to intraoperatively detect sentinel lymph node metastases in breast cancer. OSNA has also been proposed in endometrial cancer, but evidence in this regard is unclear to define the diagnostic accuracy of OSNA in detecting lymph node metastases in endometrial cancer. A systematic review and meta-analysis was performed by searching 8 electronic databases from their inception to March 2019 for studies testing the diagnostic accuracy of OSNA in detecting sentinel lymph node metastasis in endometrial cancer. Pathologic ultrastaging was the reference standard. Sensitivity, specificity, positive and negative likelihood ratio (LR+ and LR-), diagnostic odds ratio (DOR) and area under the curve (AUC) on SROC curve were calculated. Four studies with 237 patients and 691 lymph nodes were included. OSNA showed sensitivity = 0.88, specificity = 0.93, LR + =17.95, LR- = 0.15, DOR = 191.23 and high diagnostic accuracy (AUC = 0.959). OSNA appears as a highly accurate tool for intraoperative assessment of sentinel lymph node in endometrial cancer.

Keywords: Endometrial cancer; Intraoperative; OSNA; Sentinel lymph node; Tailored medicine; Ultrastaging.

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