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. 2019 Nov;62(11):1084-1091.
doi: 10.1111/myc.12993. Epub 2019 Sep 9.

Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations

Simin Taghipour  1 , Ivan M Pchelin  2 , Ali Zarei Mahmoudabadi  1 , Saham Ansari  3 , Farzad Katiraee  4 , Abdollah Rafiei  1 , Tahereh Shokohi  5 , Mahdi Abastabar  5 , Anastasia E Taraskina  2 , Firoozeh Kermani  5 , Kambiz Diba  6 , Sadegh Nouripour-Sisakht  7 , Mohammad Javad Najafzadeh  8 , Keyvan Pakshir  9 , Kamiar Zomorodian  9 , Kazem Ahmadikia  10 , Ali Rezaei-Matehkolaei  1
Affiliations

Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations

Simin Taghipour et al. Mycoses. 2019 Nov.

Abstract

The fungi Trichophyton mentagrophytes and T interdigitale account for significant amount of dermatophytosis cases worldwide. These two dermatophytes form a species complex and have a number of ribosomal internal transcribed spacer (ITS) region genotypes, allowing simultaneous species identification and strain typing. Our aim was to describe the geographic distribution of T mentagrophytes/T interdigitale ITS region genotypes and find an association between the genotypes and clinical presentations of respective infections. We performed rDNA ITS region sequencing in 397 Iranian T mentagrophytes/T interdigitale isolates and analysed all available in GenBank entries with sequences of this kind. For the study, 515 clinical annotations were available. Statistical analysis was performed by chi-squared test and Spearman rank correlation analysis. A total of 971 sequences belonged to genotypes with at least 10 geographic annotations and were classified on the basis of exclusive occurrence in a particular region or high relative contribution to a regional sample. We discerned Asian and Oceanian ("KU496915" Type V, "KT192500" Type VIII, "KU315316"), European ("FM986750" Type III, "MF926358" Type III*, "KT285210" Type VI) and cosmopolitan ("FM986691" Type I, "JX122216" Type II, "KP132819" Type II* and "AF170453" Type XXIV) genotypes. There was statistically significant difference in the ITS genotype distribution between different affected body sites. Trichophyton mentagrophytes "KT192500" Type VIII correlated with tinea cruris, T mentagrophytes "KU496915" Type V correlated with tinea corporis, T interdigitale "JX122216" Type II correlated with tinea pedis and onychomycosis. Trichophyton mentagrophytes and T interdigitale genotypes can be associated with distinct geographic locations and particular clinical presentations.

Keywords: Trichophyton interdigitale; Trichophyton mentagrophytes; internal transcribed spacer; phylogeography; tinea.

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References

REFERENCES

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