The gut microbiota: A novel therapeutic target in Parkinson's disease?

Affiliations

¹ Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia; The University of Notre Dame Australia, School of Medicine, Sydney, NSW, Australia. Electronic address: mlub6241@uni.sydney.edu.au.
² Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.
³ Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.

Comment

Michal Lubomski et al. Parkinsonism Relat Disord. 2019 Sep.

. 2019 Sep:66:265-266.

doi: 10.1016/j.parkreldis.2019.08.010. Epub 2019 Aug 12.

¹ Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia; The University of Notre Dame Australia, School of Medicine, Sydney, NSW, Australia. Electronic address: mlub6241@uni.sydney.edu.au.
² Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.
³ Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia; Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.

No abstract available

Keywords: Gastrointestinal microbiota; Levodopa; Metabolism; Parkinson's disease; Therapy.

Comment on

Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson's disease.
van Kessel SP, Frye AK, El-Gendy AO, Castejon M, Keshavarzian A, van Dijk G, El Aidy S. van Kessel SP, et al. Nat Commun. 2019 Jan 18;10(1):310. doi: 10.1038/s41467-019-08294-y. Nat Commun. 2019. PMID: 30659181 Free PMC article.
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism.
Maini Rekdal V, Bess EN, Bisanz JE, Turnbaugh PJ, Balskus EP. Maini Rekdal V, et al. Science. 2019 Jun 14;364(6445):eaau6323. doi: 10.1126/science.aau6323. Science. 2019. PMID: 31196984 Free PMC article.