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Comment
. 2019 Oct;42(10):661-663.
doi: 10.1016/j.tins.2019.08.004. Epub 2019 Aug 22.

Damage Control in the Developing Brain: Tradeoffs and Consequences

Fernando C Alsina  1 , Debra L Silver  2
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Damage Control in the Developing Brain: Tradeoffs and Consequences

Fernando C Alsina et al. Trends Neurosci. 2019 Oct.

Abstract

Genomic surveillance is crucial for shaping brain development. However, are these mechanisms always beneficial, and can they be manipulated to ameliorate neurodevelopmental disease? A recent paper by Shi et al. (Nat. Commun., 2019) sheds light on these questions and examines the consequences of both inducing genomic instability and suppressing safeguard mechanisms for the development of the cerebral cortex.

Keywords: aneuploidy; genome stability; microcephaly.

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