Hyponatraemia in heart failure
- PMID: 31449715
- DOI: 10.1111/imj.14624
Hyponatraemia in heart failure
Abstract
Hyponatraemia is common in heart failure (HF). It is estimated that over 20% of patients admitted to hospital with HF have hyponatraemia. It has also been repeatedly shown to be a surrogate marker of increased morbidity and mortality in this specific population. This review focuses on the pathophysiology of hyponatraemia through the activation of neurohormonal cascades in HF, the clinical implications of sustained hyponatraemia and treatment options in the management of this challenging phenomenon.
Keywords: acute heart failure; chronic heart failure; hyponatraemia.
© 2019 Royal Australasian College of Physicians.
References
-
- Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O'Connor CM et al. Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J 2007; 28: 980-8.
-
- Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE. Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 2010; 170: 294-302.
-
- Riegger AJ, Liebau G. The renin-angiotensin-aldosterone system, antidiuretic hormone and sympathetic nerve activity in an experimental model of congestive heart failure in the dog. Clin Sci (Lond) 1982; 62: 465-9.
-
- Verbrugge F, Steels P, Grieten L, Nijst P, Tang W, Mullens W. Hyponatremia in acute decompensated heart failure - depletion versus dilution. JACC 2015; 65: 480-92.
-
- Swedberg K, Idanpaan-Heikkila U, Remes J. Effects of enalapril on mortality in severe congestive heart failure. Results of the cooperative north scandinavian enalapril survival study (CONSENSUS). N Engl J Med 1987; 316: 1429-35.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous
