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Review
. 2019;9(4):637-652.
doi: 10.3233/JPD-191592.

Functional Connectivity Signatures of Parkinson's Disease

Alessandro Tessitore  1   2 , Mario Cirillo  1   2 , Rosa De Micco  1   2
Affiliations
Review

Functional Connectivity Signatures of Parkinson's Disease

Alessandro Tessitore et al. J Parkinsons Dis. 2019.

Abstract

Resting-state functional magnetic resonance imaging (RS-fMRI) studies have been extensively applied to analyze the pathophysiology of neurodegenerative disorders such as Parkinson's disease (PD). In the present narrative review, we attempt to summarize the most recent RS-fMRI findings highlighting the role of brain networks re-organization and adaptation in the course of PD. We also discuss limitations and potential definition of early functional connectivity signatures to track and predict future PD progression. Understanding the neural correlates and potential predisposing factors of clinical progression and complication will be crucial to guide novel clinical trials and to foster preventive strategies.

Keywords: Functional MRI; Parkinson’s disease; biomarkers; imaging; resting-state networks.

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Conflict of interest statement

The authors have no conflict of interest to report.

Figures

Fig.1
Fig.1
Most reported resting-state functional connectivity networks in healthy controls. Mean resting-state functional MRI imaging networks shown in axial view and three-dimensional reconstructions (p < 0.05 corrected). Colors represent percentage BOLD signal change, overlaid on the average anatomic images in standard space. DMN, default-mode network; SN, salience network; CEN, central executive network; DAN, dorsal attention network; SMN, sensorimotor network; VS, visual network; AN, auditory network.
See this image and copyright information in PMC

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