Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 23;8(9):1288.
doi: 10.3390/jcm8091288.

Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial

Lara Edbrooke  1   2 , Catherine L Granger  3   4 , Ross A Clark  5 , Linda Denehy  6   7
Affiliations

Physical Activity Levels Are Low in Inoperable Lung Cancer: Exploratory Analyses from a Randomised Controlled Trial

Lara Edbrooke et al. J Clin Med. .

Abstract

Background: In inoperable lung cancer, evidence is limited regarding physical activity (PA) and associations with other outcomes.

Aims: in the usual care (UC) group of an RCT to (1) explore whether baseline PA was associated with improved follow-up outcomes, (2) identify baseline variables associated with higher follow-up PA and in all RCT participants, to (3) analyse patterns of objectively measured PA, and (4) report on characteristics of those who were able to maintain or increase PA levels.

Methods: exploratory analyses of an assessor-blinded RCT. Outcomes, assessed at baseline, nine weeks and six months, included PA (seven-days of accelerometry), six-minute walk distance (6MWD), muscle strength, symptoms, mood and health-related quality of life (HRQoL).

Results: 92 participants were randomised, 80 completed baseline accelerometry (39 intervention group (IG), 41 UC), characteristics: mean (SD) age 63.0 (12.3) years, 56% male, 51% stage IV disease. Baseline PA: median (IQR) steps/day 2859.6 (2034.0-3849.2) IG versus 3195.2 (2161.2-4839.0) UC. Associations between baseline PA and six-month outcomes were significant for HRQoL and 6MWD. PA at six months was significantly associated with baseline age, 6MWD and quadriceps strength. Between-group change score (steps/day) mean differences (95% CI) at nine weeks (174.5 (-1504.7 to 1853.7), p = 0.84) and six months (574.0 (-1162.3 to 2310.3), p = 0.52).

Conclusions: further research is required to determine patient subgroups deriving the greatest benefits from PA interventions.

Keywords: exercise; lung cancer; physical activity; quality of life; symptoms.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
Flow of participants through the trial with valid objective physical activity (PA) measures.
Figure 2
Figure 2
Baseline PA levels: (A) Steps per day (number); (B) 10+ min step bouts (number of bouts per day); (C) 10+ min step bout duration (minutes); (D) 10+ min step bout cadence (steps per minute). Values are median (interquartile range).
See this image and copyright information in PMC

References

    1. Hupin D., Roche F., Gremeaux V., Chatard J.C., Oriol M., Gaspoz J.M., Barthelemy J.C., Edouard P. Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged >/=60 years: A systematic review and meta-analysis. Br. J. Sports Med. 2015;49:1262–1267. doi: 10.1136/bjsports-2014-094306. - DOI - PubMed
    1. Bellettiere J., Winkler E.A.H., Chastin S.F.M., Kerr J., Owen N., Dunstan D.W., Healy G.N. Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults. PLoS ONE. 2017;12:e0180119. doi: 10.1371/journal.pone.0180119. - DOI - PMC - PubMed
    1. de Rezende L.F., Rodrigues Lopes M., Rey-Lopez J.P., Matsudo V.K., Luiz Odo C. Sedentary behavior and health outcomes: An overview of systematic reviews. PLoS ONE. 2014;9:e105620. doi: 10.1371/journal.pone.0105620. - DOI - PMC - PubMed
    1. Grontved A., Hu F.B. Television viewing and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: A meta-analysis. JAMA. 2011;305:2448–2455. doi: 10.1001/jama.2011.812. - DOI - PMC - PubMed
    1. Healy G.N., Matthews C.E., Dunstan D.W., Winkler E.A., Owen N. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur. Heart J. 2011;32:590–597. doi: 10.1093/eurheartj/ehq451. - DOI - PMC - PubMed

LinkOut - more resources