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. 2019 Oct 14;58(42):15120-15127.
doi: 10.1002/anie.201909560. Epub 2019 Sep 5.

Renal-clearable Molecular Semiconductor for Second Near-Infrared Fluorescence Imaging of Kidney Dysfunction

Jiaguo Huang  1 , Chen Xie  2 , Xiaodong Zhang  3 , Yuyan Jiang  1 , Jingchao Li  1 , Quli Fan  2 , Kanyi Pu  1
Affiliations

Renal-clearable Molecular Semiconductor for Second Near-Infrared Fluorescence Imaging of Kidney Dysfunction

Jiaguo Huang et al. Angew Chem Int Ed Engl. .

Abstract

Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-to-background ratio (SBR). Herein, a second near-infrared (NIR-II) fluorescent molecular semiconductor (CDIR2) is synthesized for real-time imaging of kidney dysfunction in living mice. CDIR2 not only has a high renal clearance efficiency (≈90 % injection dosage at 24 h post-injection), but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents.

Keywords: kidney dysfunction; molecular probes; renal clearance; second near-infrared imaging.

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