Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 14;5(8):e02150.
doi: 10.1016/j.heliyon.2019.e02150. eCollection 2019 Aug.

Exploration of the effect of human papillomavirus (HPV) vaccination in a cohort of pregnant women in Montreal, 2010-2016

El Hadji Malick Sarr  1 , Marie-Hélène Mayrand  2   3 , François Coutlée  4 , Joseph Niyibizi  1 , Louise Laporte  5 , Patricia Monnier  6 , Ana Maria Carceller  7 , Jacques Lacroix  8 , François Audibert  9 , Marie-Josée Bédard  10 , Isabelle Girard  11 , Paul Brassard  12 , William D Fraser  13 , Helen Trottier  1 ; HERITAGE study group
Collaborators, Affiliations

Exploration of the effect of human papillomavirus (HPV) vaccination in a cohort of pregnant women in Montreal, 2010-2016

El Hadji Malick Sarr et al. Heliyon. .

Abstract

HPV vaccination efficacy has been shown in clinical trials but it is important to verify population level vaccine effectiveness (VE). We aimed to explore VE and herd effect using HPV infection data from a cohort study of Canadian pregnant women. We analyzed the baseline data of the HERITAGE study, which includes pregnant women recruited in Montreal between 2010-2012 and 2015-2016. Cervicovaginal samples self-collected in the first trimester were tested for 36 HPV types. Vaccination status was self-reported. VE and 95% confidence intervals (CI) were estimated by comparing the prevalence of HPV between vaccinated and unvaccinated women. Herd effect was explored by comparing HPV prevalence in unvaccinated women between the 2 recruitment periods. Adjusted ORs (95%CI) were estimated using exact logistic regression. The proportion of vaccinated women with at least one dose of 4vHPV was 7.5%. Although most of them were vaccinated after the onset of sexual activity, a high VE was found for HPV-16/18 (86.1% (95%CI: 15.0-99.7)). For HPV-6/11/16/18 and for HPV-31/33/45, VE was 61.9% (-23.5-92.6) and 57.0% (-47.7-92.0%), respectively. We also observed a non-statistically significant reduction in the prevalence of HPV-6/11/16/18 and HPV-31/33/45 among unvaccinated women recruited during the second recruitment period (adjusted OR: 0.8 (0.4-1.8) and 0.8 (0.3-1.7), respectively).

Keywords: Cross-protection; Gardasil®; HPV vaccination; Herd effect; Human Papillomavirus (HPV); Vaccine effectiveness; Vaccines.

PubMed Disclaimer

References

    1. Bruni L., Diaz M., Castellsague X., Ferrer E., Bosch F.X., de Sanjose S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J. Infect. Dis. 2010;202(12):1789–1799. - PubMed
    1. Burchell A.N., Tellier P.P., Hanley J., Coutlee F., Franco E.L. Human papillomavirus infections among couples in new sexual relationships. Epidemiology. 2010;21(1):31–37. - PMC - PubMed
    1. Hamlin-Douglas L.K., Coutlee F., Roger M., Franco E.L., Brassard P. Prevalence and age distribution of human papillomavirus infection in a population of inuit women in nunavik, Quebec. Cancer Epidemiol. Biomark. Prev. 2008;17(11):3141–3149. - PubMed
    1. Richardson H., Franco E., Pintos J., Bergeron J., Arella M., Tellier P. Determinants of low-risk and high-risk cervical human papillomavirus infections in Montreal University students. Sex. Transm. Dis. 2000;27(2):79–86. - PubMed
    1. Richardson H., Kelsall G., Tellier P., Voyer H., Abrahamowicz M., Ferenczy A. The natural history of type-specific human papillomavirus infections in female university students. Cancer Epidemiol. Biomark. Prev. 2003;12(6):485–490. - PubMed

LinkOut - more resources