Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Oct;10(10):2050-2053.
doi: 10.1111/1759-7714.13182. Epub 2019 Aug 27.

Multiple metachronous rare primary malignant tumors: A case report

Xiaozhen Ying  1 , Heying Zhang  2 , Bizheng Chen  1 , He Wu  1 , Liming Bao  1 , Shi Qian  3 , Xihui Ying  3
Affiliations
Case Reports

Multiple metachronous rare primary malignant tumors: A case report

Xiaozhen Ying et al. Thorac Cancer. 2019 Oct.

Abstract

Multiple primary malignant tumors (MPMTs) are rarely seen among the patients with malignant neoplasms. Moreover, the existence of five MPMTs in the same patient is an extremely rare phenomenon. In this case, a 42-year-old male patient developed five metachronous MPMTs within 16 years and the duration between each malignant tumor shortened with the progression of the disease. Multidisciplinary treatments were used on this patient and he fought against the cancers until the end of his life. Our report provides us with a new awareness of MPMTs, which should be considered when we come across with cancer patients who develop various unexplainable symptoms after the diagnosis of the first neoplasm.

Keywords: Bladder cancer; colon cancer; histopathological analysis; lung cancer; multiple primary malignant tumors.

PubMed Disclaimer

Figures

Figure 1
Figure 1
(a) Sigmoid colon cancer was diagnosed in June 1997. (b) Ascending colon carcinoma was diagnosed in October 2003. (c) Urinary tract cancer was diagnosed in April 2009. (d) Bladder cancer was diagnosed in October 2010, (HE staining, 100x).
Figure 2
Figure 2
In September 2011, two new masses were evident. (a) A 5.2 x 5.8 cm mass at the supraclavicular edge. (b,c) A mass in the right upper lobe of the lung. (d) A pathological diagnosis of squamous cell carcinoma was made (HE staining, 100x).
Figure 3
Figure 3
This illustrates the progression of the malignancies.
See this image and copyright information in PMC

References

    1. Billroth T. General surgical pathology and therapy. Guidance for students and physicians. Lecture. Khirurgiia (Mosk) 1991; 10: 136–43. - PubMed
    1. Warren S, Gates O. Multiple primary malignant tumors: A survey of the literature and a statistical study. Am J Cancer 1932; 16 (11): 1358–414.
    1. Liu Z, Liu C, Guo W, Li S, Bai O. Clinical analysis of 152 cases of multiple primary malignant tumors in 15,398 patients with malignant tumors. PLoS One 2015; 10: e0125754. - PMC - PubMed
    1. Travis LB, Rabkin CS, Brown LM et al Cancer survivorship‐‐genetic susceptibility and second primary cancers: Research strategies and recommendations. J Natl Cancer Inst 2006; 98: 15–25. - PubMed
    1. Demandante CG, Troyer DA, Miles TP. Multiple primary malignant neoplasms: Case report and a comprehensive review of the literature. Am J Clin Oncol 2003; 26: 79–83. - PubMed

Publication types

LinkOut - more resources