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Comment
. 2019 Oct;30(10):685-687.
doi: 10.1016/j.tem.2019.08.003. Epub 2019 Aug 24.

ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly

Ruben Quintana-Cabrera  1 , Maria Eugenia Soriano  2
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ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly

Ruben Quintana-Cabrera et al. Trends Endocrinol Metab. 2019 Oct.

Abstract

Assembly factors are necessary for the formation of mitochondrial supercomplexes (SCs) and in making cellular respiration more efficient. In a recent study, Balsa et al. (Mol. Cell, 2019) report that nutrient-induced endoplasmic reticulum (ER) stress engages PERK-eIF2α-mediated transcription of the SCs assembly factor SCAF1, events that coordinate ER stress and SCs formation to improve bioenergetics.

Keywords: ER stress; SCAF1; glucose deprivation; mitochondrial cristae; supercomplexes.

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