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. 2019 Nov;42(11):1601-1608.
doi: 10.1111/jfd.13077. Epub 2019 Aug 28.

Aeromonas salmonicida infects Atlantic salmon (Salmo salar) erythrocytes

Katherinne Valderrama  1 , Manuel Soto-Dávila  1 , Cristopher Segovia  1 , Ignacio Vásquez  1 , My Dang  1 , Javier Santander  1
Affiliations

Aeromonas salmonicida infects Atlantic salmon (Salmo salar) erythrocytes

Katherinne Valderrama et al. J Fish Dis. 2019 Nov.

Abstract

Aeromonas salmonicida subsp. salmonicida (hereafter A. salmonicida) is the aetiological agent of furunculosis in marine and freshwater fish. Once A. salmonicida invade the fish host through skin, gut or gills, it spreads and colonizes the head kidney, liver, spleen and brain. A. salmonicida infects leucocytes and exhibits an extracellular phase in the blood of the host; however, it is unknown whether A. salmonicida have an intraerythrocytic phase. Here, we evaluate whether A. salmonicida infects Atlantic salmon (Salmo salar) erythrocytes in vitro and in vivo. A. salmonicida did not kill primary S. salar erythrocytes, even in the presence of high bacterial loads, but A. salmonicida invaded the S. salar erythrocytes in the absence of evident haemolysis. Naïve Atlantic salmon smolts intraperitoneally infected with A. salmonicida showed bacteraemia 5 days post-infection and the presence of intraerythrocytic A. salmonicida. Our results reveal a novel intraerythrocytic phase during A. salmonicida infection.

Keywords: Aeromonas salmonicida; Salmo salar; erythrocytes; furunculosis.

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References

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