Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Monty Montano^{1

2}, Shalender Bhasin^{1

2}, Richard T D'Aquila³, Kristine M Erlandson⁴, William J Evans⁵, Nicholas T Funderburg⁶, Amy Justice^{7

8}, Lishomwa C Ndhlovu⁹, Bisola Ojikutu¹⁰, Marco Pahor¹¹, Savita Pahwa¹², Alice S Ryan^{13

14}, Jennifer Schrack¹⁵, Michael B Schultz¹⁶, Paola Sebastiani¹⁷, David A Sinclair¹⁶, Julia Tripp¹⁸, Bruce Walker¹⁹, Julie A Womack^{8

20}, Raymond Yung²¹, R Keith Reeves^{19

22}

Affiliations

¹ Boston Pepper OAIC, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
³ Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
⁴ Division of Infectious Disease, University of Colorado, Aurora, Colorado.
⁵ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California.
⁶ Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, Ohio.
⁷ Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁸ VA Connecticut Healthcare System, West Haven, Connecticut.
⁹ Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
¹⁰ Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
¹¹ Institute on Aging, Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, Florida.
¹² Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida.
¹³ Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
¹⁴ Baltimore Veterans Affairs Geriatric Research Education and Clinical Center and Research and Development Service, Baltimore, Maryland.
¹⁵ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
¹⁶ Department of Genetics, Paul F. Glenn Labs for the Biology of Aging, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.
¹⁷ Department of Biostatistics, Boston University, Boston, Massachusetts.
¹⁸ Harvard University Center for AIDS Research, Cambridge, Massachusetts.
¹⁹ Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
²⁰ Yale School of Nursing, West Haven, Connecticut.
²¹ Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
²² Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

PMID: 31456412
PMCID: PMC6862961
DOI: 10.1089/AID.2019.0130

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Monty Montano et al. AIDS Res Hum Retroviruses. 2019 Nov-Dec.

. 2019 Nov-Dec;35(11-12):999-1012.

doi: 10.1089/AID.2019.0130. Epub 2019 Sep 23.

Authors

Affiliations

¹ Boston Pepper OAIC, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
² Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
³ Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
⁴ Division of Infectious Disease, University of Colorado, Aurora, Colorado.
⁵ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California.
⁶ Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, Ohio State University, Columbus, Ohio.
⁷ Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.
⁸ VA Connecticut Healthcare System, West Haven, Connecticut.
⁹ Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
¹⁰ Division of Global Health Equity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
¹¹ Institute on Aging, Department of Aging and Geriatric Research, College of Medicine, University of Florida, Gainesville, Florida.
¹² Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida.
¹³ Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
¹⁴ Baltimore Veterans Affairs Geriatric Research Education and Clinical Center and Research and Development Service, Baltimore, Maryland.
¹⁵ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
¹⁶ Department of Genetics, Paul F. Glenn Labs for the Biology of Aging, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.
¹⁷ Department of Biostatistics, Boston University, Boston, Massachusetts.
¹⁸ Harvard University Center for AIDS Research, Cambridge, Massachusetts.
¹⁹ Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.
²⁰ Yale School of Nursing, West Haven, Connecticut.
²¹ Division of Geriatric and Palliative Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
²² Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

PMID: 31456412
PMCID: PMC6862961
DOI: 10.1089/AID.2019.0130

Abstract

People aging with HIV (PAWH) infection experience greater impairments in physical and cognitive function, in addition to higher rates of peripheral comorbid conditions (e.g., renal failure, diabetes, bone fracture, hypertension, cardiovascular disease, polypharmacy, and multimorbidity). While multifactorial drivers, including HIV infection itself, antiretroviral therapy-related toxicities, disparities in care, and biobehavioral factors, likely contribute, there remains an overarching question as to what are the relevant age-related mechanisms and models that could inform interventions that promote health span and life span in PAWH? This workshop was convened to hear from experts on the biology of aging and HIV researchers studying PAWH to focus on advancing investigations at the interface of HIV and Aging. In this study, we summarize the discussions from the Harvard Center for AIDS Research and Boston Claude D. Pepper cosponsored workshop on HIV and Aging, which took place in October 2018.

Keywords: HIV; aging; frailty; immune activation.

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Conflict of interest statement

K.M.E. has served as a consultant for Gilead and ViiV. D.A.S. is a founder, equity owner, board member, advisor to, director of, consultant to, investor in, and/or inventor on patents licensed to Vium, Jupiter Orphan Therapeutics, Cohbar, Galilei Biosciences, GlaxoSmithKline, OvaScience, EMD Millipore, Wellomics, Inside Tracker, Caudalie, Bayer Crop Science, Longwood Fund, Zymo Research, EdenRoc Sciences [and affiliates Arc-Bio, Dovetail Genomics, Claret Bioscience, Revere Biosensors, UpRNA and MetroBiotech (an NAD booster company), and Liberty Biosecurity], and Life Biosciences [and affiliates Selphagy, Senolytic Therapeutics, Spotlight Biosciences, Animal Biosciences, Iduna, Immetas, Prana, Continuum Biosciences, Jumpstart Fertility (an NAD booster company), and Lua Communications]. D.A.S. sits on the board of directors of both companies. D.A.S. is an inventor on a patent application filed by Mayo Clinic and Harvard Medical School that has been licensed to Elysium Health; his personal royalty share is directed to the Sinclair laboratory. For more information see https://genetics.med.harvard.edu/sinclair-test/people/sinclair-other.php All other authors report no disclosures.

References

1. Gomes AP, Price NL, Ling AJ, et al. : Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell 2013;155:1624–1638 - PMC - PubMed
1. Barzilai N, Crandall JP, Kritchevsky SB, Espeland MA: Metformin as a tool to target aging. Cell Metab 2016;23:1060–1065 - PMC - PubMed
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1. Mannick JB, Del Giudice G, Lattanzi M, et al. : mTOR inhibition improves immune function in the elderly. Sci Transl Med 2014;6:268ra179 - PubMed
1. Mannick JB, Morris M, Hockey HP, et al. : TORC1 inhibition enhances immune function and reduces infections in the elderly. Sci Transl Med 2018;10:449 DOI: 10.1126/scitranslmed.aaq1564 - DOI - PubMed

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Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Affiliations

Harvard HIV and Aging Workshop: Perspectives and Priorities from Claude D. Pepper Centers and Centers for AIDS Research

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical