Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2019 Aug;24(34):1900022.
doi: 10.2807/1560-7917.ES.2019.24.34.1900022.

Antimicrobial use trends, Israel, 2012 to 2017

Yaakov Dickstein  1 , Elizabeth Temkin  1 , Debby Ben-David  1 , Yehuda Carmeli  1   2 , Mitchell J Schwaber  1   2
Affiliations
Observational Study

Antimicrobial use trends, Israel, 2012 to 2017

Yaakov Dickstein et al. Euro Surveill. 2019 Aug.

Abstract

BackgroundIn 2012, Israel's National Center for Infection Control initiated a national stewardship programme that included mandatory annual reporting of antimicrobial use. Here we present nationwide Israeli data for the period 2012 to 2017.AimThe goal of this study was to detect trends in antimicrobial use in Israel following the introduction of the stewardship programme, as part of an assessment of the programme's impact.MethodsIn this retrospective observational study, data were collected from Israel's health maintenance organisations (HMOs), acute care hospitals and post-acute care hospitals (PACHs). Acute care hospital data were collected for general medical and surgical wards, and medical/surgical intensive care units (ICUs). Data were converted into defined daily doses (DDD), with use rates presented as DDD per 1,000 insured/day in the community and DDD per 100 patient-days in hospitals and PACHs. Trends were analysed using linear regression.ResultsAntimicrobial use decreased across sectors between 2012 and 2017. In the community, the decrease was modest, from 22.8 to 21.8 DDD per 1,000 insured per day (4.4%, p = 0.004). In acute care hospitals, antibiotic DDDs per 100 patient-days decreased from 100.0 to 84.0 (16.0%, p = 0.002) in medical wards, from 112.8 to 94.2 (16.5%, p = 0.004) in surgical wards and from 154.4 to 137.2 (11.1%, p = 0.04) in ICUs. Antimicrobial use decreased most markedly in PACHs, from 29.1 to 18.1 DDD per 100 patient-days (37.8%, p = 0.005).ConclusionBetween 2012 and 2017, antimicrobial use decreased significantly in all types of healthcare institutions in Israel, following the introduction of the nationwide antimicrobial stewardship programme.

Keywords: Israel; antibiotic; antimicrobial use; post-acute care hospital; stewardship; surveillance.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Antimicrobial use by patient population, Israel, 2012–2017
Figure 2
Figure 2
Antimicrobial use in the community by antibiotic category, Israel, 2012–2017
Figure 3
Figure 3
Antimicrobial use in the community, comparison with ESAC-Net 2017 data, Israel, 2012–2017
Figure 4
Figure 4
Antimicrobial use in acute care hospitals by antimicrobial category and ward, Israel, 2012–2017
Figure 5
Figure 5
Antimicrobial use in post-acute care hospitals by antimicrobial category, Israel, 2012–2017
See this image and copyright information in PMC

References

    1. European Centre for Disease Prevention and Control (ECDC). Antimicrobial consumption. In: ECDC. Annual epidemiological report 2017. Stockholm: ECDC; 2018. Available from: https://ecdc.europa.eu/sites/portal/files/documents/ESAC-NET-reportAER-2...
    1. Van Boeckel TP, Gandra S, Ashok A, Caudron Q, Grenfell BT, Levin SA, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742-50. 10.1016/S1473-3099(14)70780-7 - DOI - PubMed
    1. Gaygısız Ü, Lajunen T, Gaygısız E. Socio-economic factors, cultural values, national personality and antibiotics use: A cross-cultural study among European countries. J Infect Public Health. 2017;10(6):755-60. 10.1016/j.jiph.2016.11.011 - DOI - PubMed
    1. European Centre for Disease Prevention and Control (ECDC). Summary of the latest data on antibiotic resistance in the European Union: EARS-Net surveillance data. Stockholm: ECDC; November 2017. Available from: https://ecdc.europa.eu/sites/portal/files/documents/EAAD%20EARS-Net%20su...
    1. Pan American Health Organization (PAHO). Informe anual de la red de monitoreo/vigilanciade la resistencia a los antibióticos y de infecciones asociadas a la atención de la salud – 2014. [Annual Report of the Network for Monitoring/Surveillance of Antibiotic Resistance and Health Care Associated Infections – 2014]. Goiânia: PAHO; 2014. [Accessed 15 Aug 2019]. Spanish. Available from: https://www.paho.org/hq/dmdocuments/2017/2014-cha-informe-anual-relavra.pdf

Publication types

MeSH terms