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Comparative Study
. 2020 Feb;61(2):148-156.
doi: 10.1111/jcpp.13115. Epub 2019 Aug 28.

Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood

Christine Anderl  1 , Gu Li  1 , Frances S Chen  1
Affiliations
Comparative Study

Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood

Christine Anderl et al. J Child Psychol Psychiatry. 2020 Feb.

Abstract

Background: Previous evidence suggests that use of oral contraceptives (OCs), especially during adolescence, may increase women's vulnerability to depression in the short term. Here, we investigate whether women who had first used OC in adolescence show an increased prevalence of depression in the long term.

Methods: We examined 1,236 women in the United States National Health and Nutrition Examination Survey for whom information on depression and age at first OC use was publicly available. We compared women who reported first use of OCs in adolescence to women who had never used OCs and women who had first used OCs in adulthood on 1-year prevalence of major depressive disorder (MDD) assessed by trained interviewers.

Results: Compared with women who had used OCs during adolescence, women who had never used OCs were less likely to meet the criteria for MDD within the past year in adulthood [odds ratio (OR) = 0.31, 95% CI = 0.16-0.60], and so were women who only started using OCs in adulthood (OR = 0.54, 95% CI = 0.30-0.95). Third factors that have previously been proposed to explain the relationship between OC use and depression risk such as age at sexual debut, and, importantly, current OC use, did not account for the results in propensity score analyses.

Conclusions: We show a long-term association between adolescent OC use and depression risk in adulthood regardless of current OC use. Our findings suggest that adolescence may be a sensitive period during which OC use could increase women's risk for depression, years after first exposure.

Keywords: NHANES; Oral contraceptive use; adolescence; depression; sensitive period.

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References

    1. Ahmed, E.I., Zehr, J.L., Schulz, K.M., Lorenz, B.H., DonCarlos, L.L., & Sisk, C.L. (2008). Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions. Nature Neuroscience, 11, 995-997.
    1. Berenbaum, S.A., & Beltz, A.M. (2011). Sexual differentiation of human behavior: Effects of prenatal and pubertal organizational hormones. Frontiers in Neuroendocrinology, 32, 183-200.
    1. Bracht, T., Linden, D., & Keedwell, P. (2015). A review of white matter microstructure alterations of pathways of the reward circuit in depression. Journal of Affective Disorders, 187, 45-53.
    1. Brookhart, M.A., Schneeweiss, S., Rothman, K.J., Glynn, R.J., Avorn, J., & Stürmer, T. (2006). Variable selection for propensity score models. American Journal of Epidemiology, 163, 1149-1156.
    1. Cahill, L. (2018). How does hormonal contraception affect the developing human adolescent brain? Current Opinion in Behavioral Sciences, 23, 131-135.

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