Ambient air pollution is associated with pediatric pneumonia: a time-stratified case-crossover study in an urban area

Abstract

Background: Pneumonia, the leading reason underlying childhood deaths, may be triggered or exacerbated by air pollution. To date, only a few studies have examined the association of air pollution with emergency department (ED) visits for pediatric pneumonia, with inconsistent results. Therefore, we aimed to elucidate the impact of short-term exposure to particulate matter (PM) and other air pollutants on the incidence of ED visits for pediatric pneumonia.

Methods: PM_2.5, PM₁₀, and other air pollutant levels were measured at 11 air quality-monitoring stations in Kaohsiung City, Taiwan, between 2008 and 2014. Further, we extracted the medical records of non-trauma patients aged ≤17 years and who had visited an ED with the principal diagnosis of pneumonia. A time-stratified case-crossover study design was employed to determine the hazard effect of air pollution in a total of 4024 patients.

Results: The single-pollutant model suggested that per interquartile range increment in PM_2.5, PM₁₀, nitrogen dioxide (NO₂), and sulfur dioxide (SO₂) on 3 days before the event increased the odds of pediatric pneumonia by 14.0% [95% confidence interval (CI), 5.1-23.8%], 10.9% (95% CI, 2.4-20.0%), 14.1% (95% CI, 5.0-24.1%), and 4.5% (95% CI, 0.8-8.4%), respectively. In two-pollutant models, PM_2.5 and NO₂ were significant after adjusting for PM₁₀ and SO₂. Subgroup analyses showed that older children (aged ≥4 years) were more susceptible to PM_2.5 (interaction p = 0.024) and children were more susceptible to NO₂ during warm days (≥26.5 °C, interaction p = 0.011).

Conclusions: Short-term exposure to PM_2.5 and NO₂ possibly plays an important role in pediatric pneumonia in Kaohsiung, Taiwan. Older children are more susceptible to PM_2.5, and all children are more susceptible to NO₂ during warm days.

Keywords: Air pollution; Particulate matter; Pediatric; Pneumonia; Season.

Fig. 1

Odds ratios (ORs) and 95% confidence intervals (CIs) for pediatric pneumonia ED visits associated with IQR increments in air pollutant levels, with adjustment for temperature and humidity. ED, emergency department; IQR, interquartile range

Fig. 2

Odds ratios (ORs) for IQR increments in (a) PM_2.5 and (b) NO₂ on lag 3 after adjustment for temperature and humidity. The x-axis represents OR with 95% confidence intervals (CIs). The warm season was from April to September. *p < 0.05. Int P, interaction p-value; IQR, interquartile range